Mechanisms of CAR T cell exhaustion and current counteraction strategies

Mechanisms of CAR T cell exhaustion and current counteraction strategies

Blog Article

The functional state of chimeric antigen receptor T (CAR T) cells determines their efficacy in vivo.Exhausted CAR Specialty Beverages T cells exhibit decreased proliferative capacity, impaired anti-tumor activity, and attenuated persistence.CAR T cell exhaustion has been recognized as a vital cause of nonresponse and relapse after CAR T cell therapy.However, the triggers and mechanisms leading to CAR T cell exhaustion remain blurry and complicated.

Therefore, it is essential to clear the regulation network of CAR T cell exhaustion and explore potent solutions.Here, we review the diverse inducers of CAR T cell exhaustion in terms of manufacture process and immunosuppressive tumor microenvironment.In addition to the admitted immune checkpoint blockade, we also describe promising strategies that may reverse Dryer Vent Cover CAR T cell exhaustion including targeting the tumor microenvironment, epigenetics and transcriptomics.